Age-Related Dopamine-Dependent Disorders

On the influence of dopamine-related genetic variation on dopamine-related disorders

On the influence of dopamine-related genetic variation on dopamine-related disorders

Stresses, Aging, and Age-Related Disorders

1 Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA 2Key Laboratory of Brain Functional Genomics, Ministry of Education and Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai 200241, China 3Department of Biochemistry and Molecular Biology, Medical School, ...

Dopamine receptor turnover rates in rat striatum are age-dependent.

The time course of recovery of [3H]spiperone binding in the rat striatum after a single injection of the irreversible antagonist N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) shows that a slower rate of regeneration/turnover of D-2 dopamine receptors occurs in mid-life-mature versus young male rats. This slower receptor recovery reflects relatively slower rates of both receptor synthesi...

Age-related decline of sleep-dependent consolidation.

Sleep-dependent memory consolidation is observed following motor skill learning: Performance improvements are greater over a 12-h period containing sleep relative to an equivalent interval without sleep. Here we examined whether older adults exhibit sleep-dependent consolidation on a sequence learning task. Participants were trained on one of two sequence learning tasks. Performance was assesse...

age related interaction of dopamine and serotonin synthesis in the striatal synaptosomes